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Acoustic Phase-Change Droplets in Ultrasound Theranostics

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SEMINARThe State Key Lab ofHigh Performance Ceramics and Superfine MicrostructureShanghai Institute of Ceramics, Chinese Academy of Sciences 

 

 

 

  中 国 科 学 院 上 海 硅 酸 盐 研 究 所 高 性 能 陶 瓷 和 超 微 结 构 国 家 重 点 实 验 室 

  Acoustic Phase-Change Droplets in Ultrasound Theranostics   

  叶秩光 教授 

  台湾新竹清华大学生医工程与环境科学系 

  时间:2016年7月15日(星期五)下午3: 00 

  地点: 2号楼607会议室(国家重点实验室) 

  欢迎广大科研人员和研究生参与讨论!

  联系人:陈航榕(5305) 

  Abstract 

  The discipline of medical imaging is expanding beyond an assessment of an atomical structure to functional imaging and anassessment of the nature and extent of disease. This advancement is made possible by recent discoveries in molecular science, which provide the opportunity to design targeted contrast agents. Current ultrasoundcontrast agents are encapsulated microbubbles and have demonstrated effectiveness in cardiology and radiology. Targeted microbubbles become identifiers of aspecific molecular signature either by their preferential uptake by a physiologic system or by specific targeting of the agent through incorporation of adhesion molecules into the microbubble shell. Recent studies have demonstrated that ultrasound sonication can vaporize superheated perfluorocarbon droplets into the gaseous phase. The so-called acoustic droplet vaporization (ADV) technique can reportedly be used to generate bubbles for facilitating vascular occlusion and ultrasound ablation, and liberate encapsulated chemotherapeutic agents in droplets for tumor treatments. During ADV, inertial cavitation occurs if the applied ultrasound pressure is greater than a particular threshold. Inertial cavitation improves the efficacy of drug delivery since it reportedly permeabilizes blood vessels and cell membranes. Based on these features, ADV shows great promise in tumor therapy and drug delivery. The ultrasound-mediated vaporization of droplets enables the loaded drugs to be instantly released from its coated shell. Our studies proposed the multi-functional droplets employed with focused ultrasound for active drugs delivery/release, mechanical cell destruction, and US/MRI targeted imaging applications, thus presenting a new strategy for ultrasound theranostics.

 
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