About Us Research People International Cooperation News Education Papers Resources Links Societies & Publications Company
Picture News
Join Us
Location:Home>SICCAS News>Seminar

Production and Characterisation of Collagen-Based Scaffolds for Soft Tissue Repair

Update time:
Text Size: A A A


Biomaterials and Tissue Engineering Research Center, Shanghai Institute of Ceramics, Chinese Academy of Sciences 


Production and Characterisation of Collagen-Based Scaffolds for Soft Tissue Repair 

Speaker:Prof. Serena M. Best 

 (University of Cambridge) 

Industry-orientated Research on Biomaterials and Medical devices 

Speaker:Dr. Xiangcheng Zhang 

 (University of Cambridge) 





Personal information:  

Prof. Serena M. Best 

Professor of Materials Science

BSc University of Surrey

PhD University of London

+44 (0)1223 334307



Research Interests 

Bioactive Ceramics, Coatings and CompositesTogether with Ruth Cameron I direct the Cambridge Centre for Medical Materials. The research aims to expand the range and performance of bioactive scaffolds in clinical applications.


Skeletal implants: Optimization of substituted hydroxyapatite bone grafts

Surface modification using bioceramics

Bioactive and bioresorbable composites for tissue engineering

Collagen Scaffolds


There have been phenomenal advances in the field of Tissue Engineering during the past 20 years. The simple ideas of tissue repair- have been replaced with cell-mediated tissue reconstruction and regeneration, and there is an increasing need for carefully designed scaffolds to deliver these cells to sites of disease or injury. The importance of pore structure and morphology have begun to be understood for soft tissue applications, but the nature of the pore interconnections is not always considered. We have investigated the physics behind production of lyophilised porous collagen scaffolds through ice crystal formation. By careful control of the mould design and processing conditions, a range of pore morphologies can be produced ranging from equiaxed to elongated and we have characterized the effects of these on cell migration. Scaffold composition is another critical consideration and there is a fine balance required between scaffold “activity” and mechanical performance. In collagen scaffolds in particular, control of the degree of crosslinking is essential to optimise, simultaneously, for both mechanical and biological performance. This talk will cover the recent work that has been undertaken to optimise the structure and properties of scaffolds for a range of clinical applications in soft tissue repair.

Personal information:  

As Principal Consultant, Dr Xiang Zhang heads the Division of Medical Materials and Devices at Lucideon.  The Division has been working on a number of pioneering projects in the area of controlled release technology, biomaterials (bioglass and bioceramic and polymer) and biosensor technology.  Dr Zhang has combined experienced in both academia (17 years) and industry (17 years).  He is a materials physicist, undertaking his PhD and postdoctoral research at Cranfield University from 1999 to 1995 where he studied mechanics and nano/micro-fracture mechanics of toughening plastics. He carried on the research at the University of Cambridge in 1999, employing synchrotron radiation SAXS/WAXS to study in-situ deformation and fracture at nanometre scale on gamma-ray-irradiated polymers (polypropylene and PEEK- polyether ether ketone), and later tribology on carbon-nano film.  Dr. Zhang’s industry experience was gained at Abbott starting from 1999, where, as Principal Scientist and, later in 2008 Principal Technologist, his work covered almost all aspects of medical materials/devices, from R&D and manufacturing support to product failure analysis.

Research Interests: Hybrid Biocomposites, Hydroxyapatite Based Materials, Controlled Release Technology, Mini-medical Devices – Biosensors


This presentation will share my view on Industry-orientated Research and organising and managing Cross Country Research projects at university/institute and industrial levels in a team manner. I will also share my research interests on biomaterials by introducing new concept of Hybrid Polymeric Biocomposites, around which I will be mainly discussing issues concerning implant requirements on Mechanics and Fracture Mechanics Properties. This will lead to examples of two families of the hybrids biocomposites for implant applications: one is bioresorbable, such as cardiovascular stents, and the other permanent, such as hip/knees/spin, a balanced view of which in theories and in industrial practices will be presented.