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Development of unique ceramic scaffolds and nanoparticles with versatile modular platform for growth factor and drug delivery into bony environments

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Biomaterials and Tissue Engineering Research Center, Shanghai Institute of Ceramics, Chinese Academy of Sciences 


  Development of unique ceramic scaffolds and nanoparticles with versatile modular platform for growth factor and drug delivery into bony environments 

  SpeakerProf. Hala Zreiqat  

   (University of Sydney) 






  The repair and regeneration of large bone defects under load has remained a major clinical challenge for orthopaedic surgeons. This presentation will provide our strategies in using three dimensional (3D) printing biomaterials platform and/or biologics to develop a cell-free therapeutics to promoting bone healing in these challenging situations.  

  Using biologics such as nanoparticles (exosomes) we demonstrated that adipose stem cells (ASCs) derived exosomes promote the proliferation, migration and osteogenic gene expression by human primary osteoblasts (HOBs), which is potentiated by preconditioning ASCs with one major inflammatory factor (TNF-α). Our findings suggest that ASC-derived exosomes might offer a promising approach to replace direct stem cell transplantation for bone repair and regeneration.  

  The presentation will also discuss our recently developed 3D printing technology to fabricate novel glass-ceramic scaffold (Sr-HT Gahnite) with distinct pore geometries for use in the regeneration of large bone defects under load or as delivery vehicles for biologics. We demonstrated that Sr-HT Gahnite scaffolds with a hexagonal pore structure, provided compressive strength of 110 MPa (comparable to cortical bone) at high porosity (70%) and interconnectivity (100%) matched by excellent bioactivity when implanted in sheep segmental tibial defect. Sr-HT Gahnite scaffold meets the requirements for bioactivity combined with the mechanical strength necessary for the regeneration of large bone defects under load. 

  Our developed scaffold and 3D printing technology, with or without biologics, opens avenues for bone regeneration in load bearing bone defects in various clinical applications including orthopaedics, dental and maxillofacial. 

  Personal information: 

  Hala Zreiqat is Professor of Biomedical Engineering at the University of Sydney and a National Health and Medical Research Senior Research Fellow in biomaterials science and engineering. She received her PhD from the Faculty of Medicine, University of New South Wales, Sydney in 1998. Upon joining the University of Sydney in 2006, she established the Tissue Engineering & Biomaterials Research Unit, which she continues to direct. Her lab works on the development of novel engineered materials and 3D printed platforms for regenerative medicine, particularly in the fields of orthopaedics, dental and maxillofacial applications. In addition, her group is interested in the development of novel nanospheres for growth factors, drug and cell delivery as well as novel injectable materials. She has published ~100 peer-reviewed research manuscripts and is primary editor of A Tissue Regeneration Approach to Bone & Cartilage Repair (Springer, 2015). Professor Zreiqat has obtained >$9.2M in competitive funding. Her pioneering development of innovative biomaterials for tissue regeneration has led to one awarded (US) and 6 provisional patents, 5 as a lead inventor, and several collaborations with inter/national industry partners.  She is the Founder and Chair of the Alliance for Design and Application in Tissue Engineering (ADATE), (2006-present), and convenor of 4 biennial ADATE international symposia. ADATE facilitates collaborations/exchanges between professors in the US, Europe, China and Australia, and includes prestigious partner Universities: Harvard University, Columbia University, Stanford University, Tufts University and Hong Kong University. She is an Advisor of the World Orthopaedic Alliance (WOA) (October 2012–present).