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Bone Cell Response to Titanium and Zirconia Dental Implant Surfaces Immobilized with Biomolecules Using Natural

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SEMINAR

The State Key Lab of

High Performance Ceramics and Superfine Microstructure

Shanghai Institute of Ceramics, Chinese Academy of Sciences

中 国 科 学 院 上 海 硅 酸 盐 研 究 所 高 性 能 陶 瓷 和 超 微 结 构 国 家 重 点 实 验 室

Bone Cell Response to Titanium and Zirconia Dental Implant Surfaces Immobilized with Biomolecules Using Natural Cross-linker

黄何雄 教授

台湾阳明大学

时间:2015年9月18日(星期五)下午 15: 30

地点: 2号楼607会议室 (国家重点实验室)

欢迎广大科研人员和研究生参与讨论!

联系人:刘宣勇(2409)

报告摘要:

We developed a surface treatment capable of improving the response of bone cells to bioinert titanium (Ti) and zirconia (ZrO2) surfaces in dental implant applications. A natural cross-linker, genipin, was used to immobilize the biomolecules on bioinert Ti and ZrO2 surfaces (type I collagen on Ti; fibronectin and bone morphogenetic protein-2 on ZrO2). The biomolecule-immobilized surfaces were expected to enhance the bone cell response. Surface morphology, chemistry, hydrophilicity, and roughness of the materials were investigated. Human bone marrow mesenchymal stem cells were used to study the characteristics of cell adhesion, migration, proliferation, mineralization, and differentiation. The biomolecule-immobilized Ti and ZrO2 surfaces were found to enhance the cellular responses in vitro and in vivo. We expect that this simple surface modification for Ti and ZrO2 has potential in dental implant applications.

 
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